The sequel to House of 1000 Corpses – the Firefly family are ambushed at their isolated home by Sheriff Wydell and a squad of armed men guns blazing – yet only Otis and his sister, Baby, manage to escape the barrage of bullets unharmed. Hiding out in a backwater motel, the wanted siblings wait to rendezvous with their errant father, Captain Spaulding, killing whoever happens to stand in their way.

Two mismatched homicide detectives are forced to team up and stop a killer from reaching his dark twisted goals. There is one small problem; the cannibalistic killer is a crooked cop who could be closer than they think! As the body count grows and the bullets fly three cops and a rat put their lives on the line to stop a mad man and his crazed cult from killing and devouring 100 women. Can Dick and Jeff figure out a way to stop the killing without killing each other?